Exosome Therapy Explained: Springs Rejuvenation Outlines Science, FDA Status, and the Stem 3 Protocol
Aventura, United States - October 25, 2026 / Springs Rejuvenation /
Springs Rejuvenation has published a formal educational overview detailing the science behind exosome therapy, its current regulatory status, and the clinic's Stem 3 Protocol across its five US locations in New York City, Los Angeles, Austin, Miami, and Atlanta. The release comes as patient inquiries about exosomes have grown alongside public confusion about what the science actually supports and what regulatory bodies have formally approved.
What Exosomes Are - and What the Science Currently Shows
At the center of the discussion is a class of biological structures known as extracellular vesicles. Exosomes are nanoscale particles secreted by cells that carry proteins, lipids, and microRNA. Researchers have studied their role in cell-to-cell communication, and laboratory findings have suggested they may help support cellular signaling processes. However, a direct distinction must be drawn between what has been observed in preclinical studies and what has been demonstrated in human clinical trials.
With exosome therapy explained more clearly for patients, Springs Rejuvenation emphasizes that while peer-reviewed research has continued to grow - including a 2021 study published in the International Journal of Molecular Sciences examining extracellular vesicles in tissue signaling - results observed in laboratory settings have not yet been replicated at the level required for regulatory approval. The science remains active, but it is still developing.
FDA Status: No Approved Exosome Product Exists
Springs Rejuvenation is direct on one point: no exosome product has received FDA approval. The FDA issued public safety notices in 2019 and 2020 warning consumers and providers about unapproved exosome products being marketed in the United States. Those notices flagged potential risks associated with products that had not gone through the FDA's formal review process. Because exosomes investigational status has not changed since those warnings were issued, Springs Rejuvenation has made regulatory transparency a central part of how it communicates with prospective patients.
The clinic states plainly that its own exosome formula is produced in an FDA-approved lab but does not carry FDA approval as a therapy. The procedures it offers are described as experimental, and the clinic advises all patients to consult with a qualified medical professional before proceeding.
The Stem 3 Protocol: A Physician-Supervised Approach
Springs Rejuvenation outlines its Stem 3 Protocol as a physician-supervised procedure combining stem cells and exosomes in a structured, multi-step process. For patients exploring exosome therapy hair applications, the clinic uses a 0.9mm micro FUE technique - a minimally invasive follicular unit extraction method - during which exosomes derived from stem cells are introduced alongside the procedure. For those considering exosome therapy joints, a separate protocol pathway involves targeted delivery to the affected area under physician oversight.
Dr. Charles Pereyra, MD, a board-certified emergency medicine physician who completed his residency at NewYork-Presbyterian Brooklyn Methodist Hospital, oversees clinical protocols at Springs Rejuvenation. Dr. Pereyra is a member of the International Society of Hair Restoration Surgery (ISHRS) and has authored three papers indexed on PubMed (NPI: 1932553963).
"Based on what we observe in patients who undergo the Stem 3 Protocol combining stem cells and exosomes, there may be a supportive effect on the areas being addressed - though individual responses vary and we are careful not to overstate what the current evidence shows," said Dr. Charles Pereyra, MD of Springs Rejuvenation.
Care Delivered Across Five US Clinics
All procedures are administered by physicians at Springs Rejuvenation's US-based clinic locations. Patients are evaluated individually, and protocols are adapted based on physician assessment rather than a uniform approach. The availability of in-person, physician-supervised care at five locations reflects the clinic's operational structure, which keeps patient oversight domestic and within a medically supervised setting.
Springs Rejuvenation continues to follow developments in exosome research and updates its clinical protocols as new peer-reviewed findings emerge. The clinic acknowledges that the field is advancing but maintains that patient communication must reflect the current state of the evidence, not projections about where it may lead.
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Our Stem Cell exosome formula is produced in an FDA approved lab, but is not an FDA approved therapy. It is currently in the experimental stages - all information provided is based on our experience with patients. Results may vary. Consult with a qualified medical professional.
About Springs Rejuvenation
Springs Rejuvenation is a physician-supervised stem cell and exosome therapy clinic operating across five US locations in New York City, Los Angeles, Austin, Miami, and Atlanta. The clinic offers the Stem 3 Protocol for hair and joint applications and is committed to transparent, evidence-informed patient communication regarding the investigational status of exosome-based procedures.
Learn more at Springs Rejuvenation
Contact Information:
Springs Rejuvenation
245 5th Ave 3rd Floor Suite 307
Aventura, Florida 10016
United States
Charles Pereyra
(305) 363-0718
https://home.springsrejuvenation.com
